14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity

We have investigated the role that S259 phosphorylation, S621 phosphorylation, and 14-3-3 binding play in regulating Raf-1 activity. We show that 14-3-3 binding, rather than Raf-1 phosphorylation, is required for the correct regulation of kinase activity. Phosphorylation of S621 is not required for...

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Bibliographic Details
Main Authors: Light, Yvonne, Paterson, Hugh, Marais, Richard
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC139778/
https://ncbi.nlm.nih.gov/pubmed/12077328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.14.4984-4996.2002
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