14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity

We have investigated the role that S259 phosphorylation, S621 phosphorylation, and 14-3-3 binding play in regulating Raf-1 activity. We show that 14-3-3 binding, rather than Raf-1 phosphorylation, is required for the correct regulation of kinase activity. Phosphorylation of S621 is not required for...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Light, Yvonne, Paterson, Hugh, Marais, Richard
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077328/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.4984-4996.2002
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