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Suppression of Akt Signaling Induces Fas Ligand Expression: Involvement of Caspase and Jun Kinase Activation in Akt-Mediated Fas Ligand Regulation

Fas and Fas ligand (FasL) expression has been detected in chronic vascular lesions, and Fas-mediated apoptosis of vascular smooth muscle cells (VSMC) may influence the integrity of the atherosclerotic plaque. Here we report that FasL is not expressed by normal VSMC, but its expression is upregulated...

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Autori principali: Suhara, Toshimitsu, Kim, Hyo-Soo, Kirshenbaum, Lorrie A., Walsh, Kenneth
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC139747/
https://ncbi.nlm.nih.gov/pubmed/11756562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.2.680-691.2002
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