Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction

The E6-associated protein (E6-AP), although originally identified as a ubiquitin ligase, has recently been shown to function as a coactivator of steroid receptor-dependent gene expression in in vitro assays. In order to determine whether E6-AP acts as a coactivator in vivo, physiological parameters...

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Detalhes bibliográficos
Main Authors: Smith, Carolyn L., DeVera, Darryll G., Lamb, Dolores J., Nawaz, Zafar, Jiang, Yong-Hui, Beaudet, Arthur L., O’Malley, Bert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139730/
https://ncbi.nlm.nih.gov/pubmed/11756548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.2.525-535.2002
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