Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

Insulin resistance markedly increases cardiovascular disease risk in people with normal glucose tolerance, even after adjustment for known risk factors such as LDL, triglycerides, HDL, and systolic blood pressure. In this report, we show that increased oxidation of FFAs in aortic endothelial cells w...

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Bibliografiske detaljer
Main Authors: Du, Xueliang, Edelstein, Diane, Obici, Silvana, Higham, Ninon, Zou, Ming-Hui, Brownlee, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395482/
https://ncbi.nlm.nih.gov/pubmed/16528409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI23354
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