Inhibition of the ATM/p53 Signal Transduction Pathway by Kaposi's Sarcoma-Associated Herpesvirus Interferon Regulatory Factor 1

Infected cells recognize viral replication as a DNA damage stress and elicit the ataxia telangiectasia-mutated (ATM)/p53-mediated DNA damage response signal transduction pathway as part of the host surveillance mechanisms, which ultimately induces the irreversible cell cycle arrest and apoptosis. Vi...

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Detalhes bibliográficos
Main Authors: Shin, Young C., Nakamura, Hiroyuki, Liang, Xiaozhen, Feng, Pinghui, Chang, Heesoon, Kowalik, Timothy F., Jung, Jae U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395370/
https://ncbi.nlm.nih.gov/pubmed/16474133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.5.2257-2266.2006
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