Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β2-subunits

Sodium channel β-subunits modulate channel gating, assembly, and cell surface expression in heterologous cell systems. We generated β2(−/−) mice to investigate the role of β2 in control of sodium channel density, localization, and function in neurons in vivo. Measurements of [(3)H]saxitoxin (STX) bi...

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Bibliografiset tiedot
Päätekijät: Chen, Chunling, Bharucha, Vandana, Chen, Yuan, Westenbroek, Ruth E., Brown, Angus, Malhotra, Jyoti Dhar, Jones, Dorothy, Avery, Christy, Gillespie, Patrick J., Kazen-Gillespie, Kristin A., Kazarinova-Noyes, Katie, Shrager, Peter, Saunders, Thomas L., Macdonald, Robert L., Ransom, Bruce R., Scheuer, Todd, Catterall, William A., Isom, Lori L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2002
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC139271/
https://ncbi.nlm.nih.gov/pubmed/12481039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212638099
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