Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations

Polycystin-1 plays an essential role in renal tubular morphogenesis, and disruption of its function causes cystogenesis in human autosomal-dominant polycystic kidney disease (ADPKD). We demonstrated that polycystin-1 undergoes cleavage at G protein coupled receptor proteolytic site in a process that...

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Détails bibliographiques
Auteurs principaux: Qian, Feng, Boletta, Alessandra, Bhunia, Anil K., Xu, Hangxue, Liu, Lijuan, Ahrabi, Ali K., Watnick, Terry J., Zhou, Fang, Germino, Gregory G.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2002
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC139255/
https://ncbi.nlm.nih.gov/pubmed/12482949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252484899
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