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High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools

To facilitate positional cloning of complex trait susceptibility loci, we are investigating methods to reduce the effort required to identify trait-associated alleles. We examined primer extension analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to screen sing...

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Detalhes bibliográficos
Main Authors: Mohlke, Karen L., Erdos, Michael R., Scott, Laura J., Fingerlin, Tasha E., Jackson, Anne U., Silander, Kaisa, Hollstein, Pablo, Boehnke, Michael, Collins, Francis S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139246/
https://ncbi.nlm.nih.gov/pubmed/12482934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262661399
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