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Genetic analysis of iron citrate toxicity in yeast: Implications for mammalian iron homeostasis

Deletion of the yeast homologue of frataxin, YFH1, results in mitochondrial iron accumulation and respiratory deficiency (petite formation). We used a genetic screen to identify mutants that modify iron-associated defects in respiratory activity in Δyfh1 cells. A deletion in the peroxisomal citrate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Opal S., Hemenway, Shawn, Kaplan, Jerry
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139245/
https://ncbi.nlm.nih.gov/pubmed/12471153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.232392299
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