Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC

In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc mutations are karyotypically unstable. These findings led to suggestions that APC acts in chromosomal segregation and that APC inactivation...

Full description

Saved in:
Bibliographic Details
Main Authors: Sieber, O. M., Heinimann, K., Gorman, P., Lamlum, H., Crabtree, M., Simpson, C. A., Davies, D., Neale, K., Hodgson, S. V., Roylance, R. R., Phillips, R. K. S., Bodmer, W. F., Tomlinson, I. P. M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC139243/
https://ncbi.nlm.nih.gov/pubmed/12486240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012679099
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items