Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC

In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc mutations are karyotypically unstable. These findings led to suggestions that APC acts in chromosomal segregation and that APC inactivation...

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Hauptverfasser: Sieber, O. M., Heinimann, K., Gorman, P., Lamlum, H., Crabtree, M., Simpson, C. A., Davies, D., Neale, K., Hodgson, S. V., Roylance, R. R., Phillips, R. K. S., Bodmer, W. F., Tomlinson, I. P. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139243/
https://ncbi.nlm.nih.gov/pubmed/12486240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012679099
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