Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth

The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines...

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Autori principali: Said, Thenaa K, Moraes, Ricardo CB, Sinha, Raghu, Medina, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2001
Soggetti:
Primary Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC13923/
https://ncbi.nlm.nih.gov/pubmed/11250759
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