Stage-Specific Action of Matrix Metalloproteinases Influences Progressive Hereditary Kidney Disease

BACKGROUND: Glomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans. Mutations or deletions involving α3(IV), α4(IV), or α5(IV) chains of type IV coll...

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Detalhes bibliográficos
Main Authors: Zeisberg, Michael, Khurana, Mona, Rao, Velidi H, Cosgrove, Dominic, Rougier, Jean-Philippe, Werner, Michelle C, Shield, Charles F, Werb, Zena, Kalluri, Raghu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1391977/
https://ncbi.nlm.nih.gov/pubmed/16509766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0030100
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