PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein
p21(WAF1/CIP1) contributes to positive and negative growth control on multiple levels. We previously mapped phosphorylation sites within the C-terminal domain of p21 that regulate proliferating cell nucear antigen binding. In the current study, a kinase has been fractionated from mammalian cells tha...
Guardat en:
| Publicat a: | EMBO J |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139104/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12485998/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf684 |
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