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Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

We have cloned cDNAs for the human homologues of the yeast Dcp1 and Dcp2 factors involved in the major (5′–3′) and NMD mRNA decay pathways. While yeast Dcp1 has been reported to be the decapping enzyme, we show that recombinant human Dcp2 (hDcp2) is enzymatically active. Dcp2 activity appears evolut...

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Udgivet i:EMBO J
Principais autores: van Dijk, Erwin, Cougot, Nicolas, Meyer, Sylke, Babajko, Sylvie, Wahle, Elmar, Séraphin, Bertrand
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139098/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12486012/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf678
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