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Solution Structure and Interaction of the Antimicrobial Polyphemusins with Lipid Membranes

The horseshoe crab cationic antimicrobial peptide polyphemusin I is highly active in vitro but not protective in mouse models of bacterial and LPS challenge, while a synthetic polyphemusin variant, PV5, was previously shown to be protective in vivo. In this study, we investigated the interaction of...

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Detalhes bibliográficos
Main Authors: Powers, Jon-Paul S., Tan, Anmin, Ramamoorthy, Ayyalusamy, Hancock, Robert E. W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386647/
https://ncbi.nlm.nih.gov/pubmed/16300399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051302m
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