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Relationship between plasma oxipurinol concentrations and xanthine oxidase activity in volunteers dosed with allopurinol.

1. 1-methyl xanthine (1-MX) is metabolized exclusively to 1-methyl uric acid (1-MU) by the enzyme xanthine oxidase. 2. The ratio of 1-MU to 1-MX in the urine, following a dose of 50 mg of 1-MX infused intravenously over 20 min, was used to measure the inhibition of xanthine oxidase induced by differ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Day, R O, Miners, J, Birkett, D J, Graham, G G, Whitehead, A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1988
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386565/
https://ncbi.nlm.nih.gov/pubmed/3190993
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