A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma

Complement component 5 (C5) has been described as either promoting or protecting against airway hyperresponsiveness (AHR) in experimental allergic asthma, suggesting pleomorphic effects of C5. Here we report that local pharmacological targeting of the C5a receptor (C5aR) prior to initial allergen se...

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Detalhes bibliográficos
Main Authors: Köhl, Jörg, Baelder, Ralf, Lewkowich, Ian P., Pandey, Manoj K., Hawlisch, Heiko, Wang, Lihua, Best, Jennifer, Herman, Nancy S., Sproles, Alyssa A., Zwirner, Jörg, Whitsett, Jeffrey A., Gerard, Craig, Sfyroera, Georgia, Lambris, John D., Wills-Karp, Marsha
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386108/
https://ncbi.nlm.nih.gov/pubmed/16511606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26582
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