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An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing

The Dbf4/Cdc7 kinase acts at the level of individual origins to promote the initiation of DNA replication. We demonstrate through both immunoprecipitation and two-hybrid assays that a domain comprising the first 296 aa of Dbf4p interacts with Orc2p and Orc3p subunits of the origin recognition comple...

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מידע ביבליוגרפי
Main Authors: Duncker, Bernard P., Shimada, Kenji, Tsai-Pflugfelder, Monika, Pasero, Philippe, Gasser, Susan M.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2002
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC138569/
https://ncbi.nlm.nih.gov/pubmed/12441400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252093999
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