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Coordination of kinesin's two heads studied with mutant heterodimers

A conventional kinesin molecule has two identical catalytic domains (heads) and is thought to use them alternately to move processively, with 8-nm steps. To clarify how each head contributes to the observed steps, we have constructed heterodimeric kinesins that consist of two distinct heads. The het...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kaseda, Kuniyoshi, Higuchi, Hideo, Hirose, Keiko
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC138564/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12451178/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252409199
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