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Coordination of kinesin's two heads studied with mutant heterodimers

A conventional kinesin molecule has two identical catalytic domains (heads) and is thought to use them alternately to move processively, with 8-nm steps. To clarify how each head contributes to the observed steps, we have constructed heterodimeric kinesins that consist of two distinct heads. The het...

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Autori principali: Kaseda, Kuniyoshi, Higuchi, Hideo, Hirose, Keiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC138564/
https://ncbi.nlm.nih.gov/pubmed/12451178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252409199
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