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Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58(IPK)
P58(IPK) is an Hsp40 family member known to inhibit the interferon (IFN)-induced, double-stranded RNA-activated, eukaryotic initiation factor 2α (eIF2α) protein kinase R (PKR) by binding to its kinase domain. We find that the stress of unfolded proteins in the endoplasmic reticulum (ER) activates P5...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC138540/ https://ncbi.nlm.nih.gov/pubmed/12446838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252341799 |
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