Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58(IPK)

P58(IPK) is an Hsp40 family member known to inhibit the interferon (IFN)-induced, double-stranded RNA-activated, eukaryotic initiation factor 2α (eIF2α) protein kinase R (PKR) by binding to its kinase domain. We find that the stress of unfolded proteins in the endoplasmic reticulum (ER) activates P5...

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Autores principales: Yan, Wei, Frank, Christopher L., Korth, Marcus J., Sopher, Bryce L., Novoa, Isabel, Ron, David, Katze, Michael G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC138540/
https://ncbi.nlm.nih.gov/pubmed/12446838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252341799
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