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Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58(IPK)

P58(IPK) is an Hsp40 family member known to inhibit the interferon (IFN)-induced, double-stranded RNA-activated, eukaryotic initiation factor 2α (eIF2α) protein kinase R (PKR) by binding to its kinase domain. We find that the stress of unfolded proteins in the endoplasmic reticulum (ER) activates P5...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yan, Wei, Frank, Christopher L., Korth, Marcus J., Sopher, Bryce L., Novoa, Isabel, Ron, David, Katze, Michael G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC138540/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12446838/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252341799
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