Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506.

Nanamolar concentrations of the immunosuppressive drug FK-506 inhibit the induction of T-lymphocyte proliferation by the lectins concanavalin A (Con A) and phytohaemagglutinin (PHA). Activation by Con A is more sensitive to inhibition than the response to PHA. FK-506 inhibits an early Ca2+-dependent...

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Bibliographic Details
Main Authors: Kay, J E, Benzie, C R, Goodier, M R, Wick, C J, Doe, S E
Format: Artigo
Language:Inglês
Published: 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1385316/
https://ncbi.nlm.nih.gov/pubmed/2475433
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