Binding of monoclonal antibody to CD16 causes calcium mobilization in large granular lymphocytes but inhibits NK killing.

A monoclonal antibody (mAb), CLB/FcR gran I, reactive with the CD16 Fc receptor (FcRlo/FcRIII) of human cells, leads to calcium mobilization in large granular lymphocytes (LGL) but not in granulocytes. Identical responses are obtained with F(ab')2 fragments of this antibody, indicating that the...

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Detalhes bibliográficos
Main Authors: Macintyre, E A, Wallace, D W, O'Flynn, K, Abdul-Gaffar, R, Tetteroo, P A, Morgan, G, Linch, D C
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1385237/
https://ncbi.nlm.nih.gov/pubmed/2564843
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