Comprehensive pharmacokinetics of a humanized antibody and analysis of residual anti-idiotypic responses.

A murine antibody to human tumour necrosis factor-alpha (TNF-alpha) (CB0010) was complementarity-determining region (CDR)-grafted using human IgG4 heavy and kappa light chain constant regions. In cynomolgus monkeys, the grafted antibody (CDP571) was eliminated with a half-life of 40-90 hr, two to th...

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Main Authors: Stephens, S, Emtage, S, Vetterlein, O, Chaplin, L, Bebbington, C, Nesbitt, A, Sopwith, M, Athwal, D, Novak, C, Bodmer, M
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383798/
https://ncbi.nlm.nih.gov/pubmed/7558164
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