Interaction with phospholipids modulates α-synuclein nitration and lipid–protein adduct formation

Intracellular aggregates of α-syn (α-synuclein) represent pathoanatomical hallmarks of neurodegenerative disorders (synucleinopathies). The molecular mechanisms underlying α-syn aggregation into filamentous inclusions may involve oxidation and nitration of the protein. Whereas the effects of oxidant...

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Autors principals: Trostchansky, Andrés, Lind, Summer, Hodara, Roberto, Oe, Tomoyuki, Blair, Ian A., Ischiropoulos, Harry, Rubbo, Homero, Souza, José M.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2005
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383693/
https://ncbi.nlm.nih.gov/pubmed/16146428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051277
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