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Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies

The cAMP signalling pathway has emerged as a key regulator of haematopoietic cell proliferation, differentiation and apoptosis. In parallel, general understanding of the biology of cyclic nucleotide PDEs (phosphodiesterases) has advanced considerably, revealing the remarkable complexity of this enzy...

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Detalhes bibliográficos
Main Authors: Lerner, Adam, Epstein, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383661/
https://ncbi.nlm.nih.gov/pubmed/16336197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051368
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