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Recruitment and activation of PLCγ1 in T cells: a new insight into old domains

Engagement of the T-cell antigen receptor leads to recruitment of phospholipase Cγ1 (PLCγ1) to the LAT-nucleated signaling complex and to PLCγ1 activation in a tyrosine phosphorylation-dependent manner. The mechanism of PLCγ1 recruitment and the role of PLCγ1 Src homology (SH) domains in this proces...

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Hlavní autoři: Braiman, Alex, Barda-Saad, Mira, Sommers, Connie L, Samelson, Lawrence E
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383559/
https://ncbi.nlm.nih.gov/pubmed/16467851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600978
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