Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response

Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral oncogenes E6 and E7 and acquisition of a selective growth advantage for cells containing integrants. Overex...

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Bibliographic Details
Main Authors: Pett, Mark R., Herdman, M. Trent, Palmer, Roger D., Yeo, Giles S. H., Shivji, Mahmud K., Stanley, Margaret A., Coleman, Nicholas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383496/
https://ncbi.nlm.nih.gov/pubmed/16505361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600078103
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