The Slow Wallerian Degeneration Protein, Wld(S), Binds Directly to VCP/p97 and Partially Redistributes It within the Nucleus

Slow Wallerian degeneration (Wld(S)) mutant mice express a chimeric nuclear protein that protects sick or injured axons from degeneration. The C-terminal region, derived from NAD(+) synthesizing enzyme Nmnat1, is reported to confer neuroprotection in vitro. However, an additional role for the N-term...

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Hauptverfasser: Laser, Heike, Conforti, Laura, Morreale, Giacomo, Mack, Till G.M., Heyer, Molly, Haley, Jane E., Wishart, Thomas M., Beirowski, Bogdan, Walker, Simon A., Haase, Georg, Celik, Arzu, Adalbert, Robert, Wagner, Diana, Grumme, Daniela, Ribchester, Richard R., Plomann, Markus, Coleman, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382299/
https://ncbi.nlm.nih.gov/pubmed/16371511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-04-0375
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