Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb

BACKGROUND: The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein Phosphatase 1 (PP1). At mitotic exit, all three PP1 isoforms, α, γ1 and δ, bind to pRb and dephosphorylate its Ser/Thr sites in a sequential and site-specific way. The pRb-C terminal has been reported...

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Détails bibliographiques
Auteurs principaux: Vietri, Michele, Bianchi, Mariarita, Ludlow, John W, Mittnacht, Sibylle, Villa-Moruzzi, Emma
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2006
Sujets:
Primary Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382259/
https://ncbi.nlm.nih.gov/pubmed/16466572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-6-3
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