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The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes.

Paroxetine is a selective serotonin reuptake inhibitor possessing anti-depressant activity. Demethylenation of the methylenedioxy phenyl group is the initial step in its metabolism, the liberated carbon appearing in vitro as formate. A radioassay involving [14C-methylenedioxy] paroxetine was develop...

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Detalhes bibliográficos
Main Authors: Bloomer, J C, Woods, F R, Haddock, R E, Lennard, M S, Tucker, G T
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1381441/
https://ncbi.nlm.nih.gov/pubmed/1388041
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