Functional Variant in a Bitter-Taste Receptor (hTAS2R16) Influences Risk of Alcohol Dependence

A coding single-nucleotide polymorphism (cSNP), K172N, in hTAS2R16, a gene encoding a taste receptor for bitter β-glucopyranosides, shows significant association with alcohol dependence (P=.00018). This gene is located on chromosome 7q in a region reported elsewhere to exhibit linkage with alcohol d...

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Auteurs principaux: Hinrichs, Anthony L., Wang, Jen C., Bufe, Bernd, Kwon, Jennifer M., Budde, John, Allen, Rebecca, Bertelsen, Sarah, Evans, Whitney, Dick, Danielle, Rice, John, Foroud, Tatiana, Nurnberger, John, Tischfield, Jay A., Kuperman, Samuel, Crowe, Raymond, Hesselbrock, Victor, Schuckit, Marc, Almasy, Laura, Porjesz, Bernice, Edenberg, Howard J., Begleiter, Henri, Meyerhof, Wolfgang, Bierut, Laura J., Goate, Alison M.
Format: Artigo
Langue:Inglês
Publié: The American Society of Human Genetics 2006
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1380207/
https://ncbi.nlm.nih.gov/pubmed/16385453
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