Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells

The interaction of activated Ras with Raf initiates signaling cascades that contribute to a significant percentage of human tumors, suggesting that agents that specifically disrupt this interaction might have desirable chemotherapeutic properties. We used a subtractive forward two-hybrid approach to...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kato-Stankiewicz, Juran, Hakimi, Irina, Zhi, Gang, Zhang, Jie, Serebriiskii, Ilya, Guo, Lea, Edamatsu, Hironori, Koide, Hiroshi, Menon, Sanjay, Eckl, Robert, Sakamuri, Sukumar, Lu, Yingchun, Chen, Quin-Zene, Agarwal, Seema, Baumbach, William R., Golemis, Erica A., Tamanoi, Fuyuhiko, Khazak, Vladimir
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137895/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391290/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.222222699
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