Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain

Protein degradation by the ubiquitin (Ub) system controls the concentrations of many regulatory proteins. The degradation signals (degrons) of these proteins are recognized by the system's Ub ligases (complexes of E2 and E3 enzymes). Two substrate-binding sites of UBR1, the E3 of the N-end rule path...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Du, Fangyong, Navarro-Garcia, Federico, Xia, Zanxian, Tasaki, Takafumi, Varshavsky, Alexander
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137845/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.172527399
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