Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain

Protein degradation by the ubiquitin (Ub) system controls the concentrations of many regulatory proteins. The degradation signals (degrons) of these proteins are recognized by the system's Ub ligases (complexes of E2 and E3 enzymes). Two substrate-binding sites of UBR1, the E3 of the N-end rule path...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Du, Fangyong, Navarro-Garcia, Federico, Xia, Zanxian, Tasaki, Takafumi, Varshavsky, Alexander
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137845/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.172527399
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