Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

On phosphorylation of Y221 by Abelson (Abl) kinase, the Crk-II adapter protein undergoes an intramolecular reorganization initiated by the binding of its own Src homology 2 (SH2) domain to the pY221 site. Conformational changes induced by phosphotyrosine recognition promote the binding of the Src ho...

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Bibliografiska uppgifter
Huvudupphovsmän: Donaldson, Logan W., Gish, Gerald, Pawson, Tony, Kay, Lewis E., Forman-Kay, Julie D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC137835/
https://ncbi.nlm.nih.gov/pubmed/12384576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212518799
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