Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

Despite extensive deposition of putatively neurotoxic amyloid-β (Aβ) protein in the brain, it has not been possible to demonstrate an association of Aβ deposits with neuronal loss in Alzheimer's disease (AD), and neuronal loss is minimal in transgenic mouse models of AD. Using triple immunostai...

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Main Authors: Urbanc, B., Cruz, L., Le, R., Sanders, J., Ashe, K. Hsiao, Duff, K., Stanley, H. E., Irizarry, M. C., Hyman, B. T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2002
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC137824/
https://ncbi.nlm.nih.gov/pubmed/12374847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222433299
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