Chromosome breakage in the Prader-Willi and Angelman syndromes involves recombination between large, transcribed repeats at proximal and distal breakpoints.

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are distinct neurobehavioral disorders that most often arise from a 4-Mb deletion of chromosome 15q11-q13 during paternal or maternal gametogenesis, respectively. At a de novo frequency of approximately.67-1/10,000 births, these deletions repres...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Amos-Landgraf, J M, Ji, Y, Gottlieb, W, Depinet, T, Wandstrat, A E, Cassidy, S B, Driscoll, D J, Rogan, P K, Schwartz, S, Nicholls, R D
Format: Artigo
Langue:Inglês
Publié: 1999
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1377936/
https://ncbi.nlm.nih.gov/pubmed/10417280
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