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The substrate binding domain of DnaK facilitates slow protein refolding

We examined the effects of a fragment of the substrate binding domain of DnaK on protein refolding from chemically denatured states. The fragment DnaK384-638, containing a full-length substrate binding domain, tightly binds to the unfolded protein in solution. The effects of DnaK384-638 on the react...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Tanaka, Naoki, Nakao, Shota, Wadai, Hiromasa, Ikeda, Shoichi, Chatellier, Jean, Kunugi, Shigeru
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137728/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12434017/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.242317099
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