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Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

Precise regulation of the evolutionarily conserved hypoxia-inducible transcription factor (HIF) ensures proper adaptation to variations in oxygen availability throughout development and into adulthood. Oxygen-dependent regulation of HIF stability and activity are mediated by hydroxylation of conserv...

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Detalhes bibliográficos
Main Authors: Dann, Charles E., Bruick, Richard K., Deisenhofer, Johann
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC137720/
https://ncbi.nlm.nih.gov/pubmed/12432100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202614999
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