Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia

The t(1;19) translocation yields a fusion between E2A and PBX1 genes and occurs in 5% of acute lymphoblastic leukemia in children and adults. We used chromosomal translocations and Ig heavy chain (IGH)/T cell antigen receptor (TCR) rearrangements to develop an understanding of the etiology and natur...

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Hauptverfasser: Wiemels, Joseph L., Leonard, Brian C., Wang, Yunxia, Segal, Mark R., Hunger, Stephen P., Smith, Martyn T., Crouse, Vonda, Ma, Xiaomei, Buffler, Patricia A., Pine, Sharon R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC137550/
https://ncbi.nlm.nih.gov/pubmed/12415113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222481199
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