Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia

The t(1;19) translocation yields a fusion between E2A and PBX1 genes and occurs in 5% of acute lymphoblastic leukemia in children and adults. We used chromosomal translocations and Ig heavy chain (IGH)/T cell antigen receptor (TCR) rearrangements to develop an understanding of the etiology and natur...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wiemels, Joseph L., Leonard, Brian C., Wang, Yunxia, Segal, Mark R., Hunger, Stephen P., Smith, Martyn T., Crouse, Vonda, Ma, Xiaomei, Buffler, Patricia A., Pine, Sharon R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137550/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12415113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.222481199
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