Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1

Accidental or drug-induced interruption of the breakage and reunion cycle of eukaryotic topoisomerase I (Top1) yields complexes in which the active site tyrosine of the enzyme is covalently linked to the 3′ end of broken DNA. The enzyme tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes this protein-DN...

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Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Liu, Chunyan, Pouliot, Jeffrey J., Nash, Howard A.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2002
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137529/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12397185/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182557199
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