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New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2

A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to study the linker influence between a <i>para</i>-...

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Principais autores: Oksana V. Salomatina, Nadezhda S. Dyrkheeva, Irina I. Popadyuk, Alexandra L. Zakharenko, Ekaterina S. Ilina, Nina I. Komarova, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2021-12-01
Series:Molecules
Assuntos:
deoxycholic acid
amide
oxadiazoles
TDP1 inhibitor
TDP2 inhibitor
cancer
Acceso en liña:https://www.mdpi.com/1420-3049/27/1/72
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