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Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced with N-methylprotoporphyrin IX, a selective inhibitor of ferrochelatase, in two human brain cell lines, SHSY5Y (neuroblas...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137500/ https://ncbi.nlm.nih.gov/pubmed/12417755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192585799 |
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