Conformational energetics of stable and metastable states formed by DNA triplet repeat oligonucleotides: Implications for triplet expansion diseases

We have embedded the hexameric triplet repeats (CAG)(6) and (CTG)(6) between two (GC)(3) domains to produce two 30-mer hairpins with the sequences d[(GC)(3)(CAG)(6)(GC)(3)] and d[(GC)(3)(CTG)(6)(GC)(3)]. This construct reduces the conformational space available to these repetitive DNA sequences. We...

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Autori principali: Völker, J., Makube, N., Plum, G. E., Klump, H. H., Breslauer, K. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC137482/
https://ncbi.nlm.nih.gov/pubmed/12417759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222519799
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