Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy

The macrolide antibiotic tylosin has been used extensively in veterinary medicine and exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin-synthesizing strains of the Gram-positive bacterium Streptomyces fradiae protect themselves from their own product by differential expres...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Liu, Mingfu, Douthwaite, Stephen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137475/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12417742/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.232580599
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