Mutations altering the cleavage specificity of a homing endonuclease
The homing endonuclease I-CreI recognizes and cleaves a particular 22 bp DNA sequence. The crystal structure of I-CreI bound to homing site DNA has previously been determined, leading to a number of predictions about specific protein–DNA contacts. We test these predictions by analyzing a set of endo...
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| Publicado en: | Nucleic Acids Res |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12202772/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf495 |
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