Mutations altering the cleavage specificity of a homing endonuclease

The homing endonuclease I-CreI recognizes and cleaves a particular 22 bp DNA sequence. The crystal structure of I-CreI bound to homing site DNA has previously been determined, leading to a number of predictions about specific protein–DNA contacts. We test these predictions by analyzing a set of endo...

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izdano v:	Nucleic Acids Res
Principais autores:	Seligman, Lenny M., Chisholm, Karen M., Chevalier, Brett S., Chadsey, Meggen S., Edwards, Samuel T., Savage, Jeremiah H., Veillet, Adeline L.
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 2002
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12202772/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf495
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